RLC-lab

CRO focused on bespoke compound library synthesis and hit-2-lead optimisation services

IMPORTANT:  COVID-19  STEM education

We are setting up a new service to help  schools during the lockdown period. Go to our dedicated STEM site at www.lab-class.com for details & to register

Fragment chemistry

Mol wt 100 to 220

 

Rotational bonds 0 to 3

 

High % sp3

 

logP -1 to 1

 

Aq solubility >10mM

 

Spiro compounds

 

Unnatural amino acids

 

Purity >98%

Pre-weighed & plated

Contact us for SDF file

Solubility

Aqueous solubility is one of the key important parameters when evaluating hit compounds

 

We can screen solid compounds or DMSO stock solutions

Automated screen to remove DMSO and measure solubility in >99% aqueous buffer

 

Kinetic and thermodynamic measurements

lipophilicity

Measurement of logP and logD

Shake flask and HPLC methodology

Solid samples or DMSO stocks

Automated screen to remove DMSO

Metabolic

stability

Metabolic stability is one of the key filter decisions when progressing hit compounds

 

Microsomes

Hepatocytes

S9 fraction

Multi species

Solid samples or DMSO stock solutions

Bioanalysis

Non GLP early stage R&D

Automated online extraction of plasma samples - no sample preparation required

Fast turn around

High throughput

Measurement of key DMPK parameters

Example Fragement set: ImAc01

 

Good aqueous solubility and stability – data supplied :  Purity > 98%  : 

Based on unnatural amino acids :  Reduced amine pka – compounds are neutral at pH 7.4

Multiple reaction sites for SAR and hit-2-lead

 

Other imidazolidone sets available:  High % Sp3  :  Aromatic/heterocyclic

 

Contact us info@rlclab.com  for full set sdf file

Contact

RLC-lab

ATIC Innovation Centre

Oakwood

Loughborough LE11 3QF

UK

email:  info@rlclab.com