RLC-lab

CRO focused on bespoke compound library synthesis and hit-2-lead optimisation services

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Fragment chemistry

Mol wt 100 to 220

Rotational bonds 0 to 3

High % sp3

logP -1 to 1

Aq solubility >10mM

Spiro compounds

Unnatural amino acids

Purity >98%

Pre-weighed & plated

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Contact us for SDF file

Solubility

Aqueous solubility is one of the key important parameters when evaluating hit compounds

We can screen solid compounds or DMSO stock solutions

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Automated screen to remove DMSO and measure solubility in >99% aqueous buffer

Kinetic and thermodynamic measurements

lipophilicity

Measurement of logP and logD

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Shake flask and HPLC methodology

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Solid samples or DMSO stocks

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Automated screen to remove DMSO

Metabolic

stability

Metabolic stability is one of the key filter decisions when progressing hit compounds

Microsomes

Hepatocytes

S9 fraction

Multi species

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Solid samples or DMSO stock solutions

Bioanalysis

Non GLP early stage R&D

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Automated online extraction of plasma samples - no sample preparation required

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Fast turn around

High throughput

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Measurement of key DMPK parameters

Example Fragement set: ImAc01

Good aqueous solubility and stability – data supplied :  Purity > 98%  : 

Based on unnatural amino acids :  Reduced amine pka – compounds are neutral at pH 7.4

Multiple reaction sites for SAR and hit-2-lead

Other imidazolidone sets available:  High % Sp3  :  Aromatic/heterocyclic

Contact us info@rlclab.com  for full set sdf file

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Contact

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RLC-lab

ATIC Innovation Centre

Oakwood

Loughborough LE11 3QF

UK

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email: