RLC-lab
CRO focused on bespoke compound library synthesis and hit-2-lead optimisation services
IMPORTANT: COVID-19 STEM education
We are setting up a new service to help schools during the lockdown period. Go to our dedicated STEM site at for details & to register
Fragment chemistry
Mol wt 100 to 220
Rotational bonds 0 to 3
High % sp3
logP -1 to 1
Aq solubility >10mM
Spiro compounds
Unnatural amino acids
Purity >98%
Pre-weighed & plated
Contact us for SDF file
Solubility
Aqueous solubility is one of the key important parameters when evaluating hit compounds
We can screen solid compounds or DMSO stock solutions
Automated screen to remove DMSO and measure solubility in >99% aqueous buffer
Kinetic and thermodynamic measurements
lipophilicity
Measurement of logP and logD
Shake flask and HPLC methodology
Solid samples or DMSO stocks
Automated screen to remove DMSO
Metabolic
stability
Metabolic stability is one of the key filter decisions when progressing hit compounds
Microsomes
Hepatocytes
S9 fraction
Multi species
Solid samples or DMSO stock solutions
Bioanalysis
Non GLP early stage R&D
Automated online extraction of plasma samples - no sample preparation required
Fast turn around
High throughput
Measurement of key DMPK parameters
Example Fragement set: ImAc01
Good aqueous solubility and stability – data supplied : Purity > 98% :
Based on unnatural amino acids : Reduced amine pka – compounds are neutral at pH 7.4
Multiple reaction sites for SAR and hit-2-lead
Other imidazolidone sets available: High % Sp3 : Aromatic/heterocyclic
Contact us info@rlclab.com for full set sdf file
Contact
RLC-lab
ATIC Innovation Centre
Oakwood
Loughborough LE11 3QF
UK
email:
